14.03.00 Медико-биологические науки

The Dynamics of Metabolic Changes Induced by the Use of Cardiopulmonary Bypass in Cardiosurgical Patients Bratsilo A. A., Zolotavina M. L., Khablyuk V. V.The use of cardiopulmonary bypass in open heart surgery gave an impulse to the study of mechanisms and ways to correct homeostasis disorders. Apart from that, any cardiosurgical operation carried out under the described conditions is inevitably accompanied by the development of toxic syndrome, the severity of which determines the postoperative course and often also the patients’ prognosis. And only laboratory support in order to evaluate the severity of surgical trauma allows the adaptive processes of the body to be assessed quickly and predicted correctly.

Agrogene Transformation and Humus State of Soil in Farmland of Orenburg Zauralye Сhernozem southern and dark chestnut soils in various farmland (virgin land, hayfield, grazing areas, fallow land, arable land) are investigated in Orenburg Zauralye. It was established that the agrogene transformation of ecosystems is associated with the following processes: 1) decrease of phytocenosis productivity on account of reducing underground biomass; 2) deterioration in the structural-aggregate state of the soils; 3) easing of the intensity of carbon dioxide emission from soils; 4) reduction of humus content (for 8% -29% of the original value); 5) changes in fractional-group composition of humus in the direction of reducing the content of GA2 fraction.

New geological and geochemical data of prospects of oil-and-gas content of deep-laying deposits of the North of Western Siberia Geological structure of deep-seated deposits in the north of Western Siberia, lithology and reservoir properties of the Jurassic and pre-Jurassic rocks, geochemical characteristics razreza were refined. Proizvedena preliminary assessment of hydrocarbon potential has made. The dependence of the quantities of hydrocarbon reserves on the deposits from paleofatsialnoy depositional environment, sediment thickness and catagenetic transformation of the original organic matter.

The ecological situation of Petrozavodsk municipal district urban forests The characteristic of the current sanitary and forest pathology conditions of 45 urban forest sections of Petrozavodsk urban district of the Republic of Karelia has been done. Data processing was conducted using GIS technologies, principal component analysis and by averaging the point estimates using the median. There were allocated 5 group sections of urban forests: minimum (17 % of total urban forest area), weak (18 %), medium (31 %), strong (4 %) and maximum (30 %) disturbed. It is proposed to use the obtained data for rational planning of urban development.

The Influence of Electromagnetic Irradiation of Millimeter Range on the Ability of Pathogenic Corynebacteria to Biofilm Formation Theoretical and experimental substantiation of millimeter waves in different frequency bands influence on the formation of pathogenic corynebacteria subpopulations with low and high ability to form biofilms is presented in the article. It was experimentally proved that electromagnetic waves in 61,0 GHz frequency range, stimulated ability of corynebacteria to form biofilms; irradiation 42,2 GHz frequency range, on the contrary, inhibited these properties.

Effect of screening plants according to grain size, the use of fertilizers, plant protection on yield and quality of seeds sown barley varieties Sobolek Butkovskaya Lydia Kuzminichna., Kuzmin Dmitriy Nikolaevich. The results of studies of responsiveness of seeds of different size of the means of chemical plant protection products and fertilizers. With the use of intensive technologies of the emergence of another species (Pallidum) in spring barley Sobolek reduced. The selection of coarse barley seeds Sobolek in primary seed, fertilizer and chemical plant protection increase the productivity of seeds to 0,15-1,22 t / ha, 1-3% germination, varietal purity of 1-2%.

Influence of changes in the physico-chemical and agrochemical indicators of chernozem soil during its anthropogenic disturbance on the yield of white mustard and urease activity of soil Technogenically disturbed soils on the basis of podzolized chernozem were modeled and studied. It is shown that disturbance of the soil leads to decreasing content of major nutrients and the deterioration of physical and chemical properties. We found the coefficients of correlation, showing the dependence of the productivity of white mustard, which were seeded at the biological stage of reclamation of disturbed soil, on the above factors.

The health status of the population of the village of Antipayuta Yamal-Nenets Autonomous district as an indicator of the quality of the living environment Unique data on the health status of the population of the Arctic zone of the Russian Federation. The demographic situation was characterized by a positive natural population increase through high birth rates and high infant mortality. Shown significant growth in environmentally related disorders of blood, blood-forming organs and certain disorders involving the immune mechanisms (due to anemia) and diseases of the digestive system.

Inbriding as the regulation factor of pathogenesis in forest ecosystems Imbreeding, as the reproduction from the mating  of  genetically related parents, is usual in the wild nature. As purposeful process, inbreeding is widely applied in selection of plants and animals. Inbreeding results in increased homozygosity. Homozygosity  can increase the chances of offspring being affected by recessive or deleterious traits. The homozygosity of  offspring    usually raises, because the number of identical alleles in their genomes of the subsequent individuals  increases. Homozygosity reduces fitness of population, weakens it, that is causes inbreeding depression. The purpose of the given work –    to use the factor of the inbreeding depressions for suppression of pathogenic  populations in forest ecosystems. Inbreeding in the ecosystems is reached as a result of reproductive isolation of pathogenic organisms. Inbreeding leads to a decreased fitness of a population. The researches were spent in the Central Russian forest-steppe. Modelling test objects were the economically significant  and well-known fungi   Erisiphe alphitoiges, Heterobasidion annosum and Porodaedalea pini.

Application of biological preparations on crops of Galega and their impact on the productivity of green mass and seeds Degunova Natalia Borisovna. Danilova Yulia Borisovna, Shkodina Elena Petrovna Discusses how to increase productivity of green mass of Galega in the first years of life, the prospects of seed production of fodder Galega with crops. The results of experiments on inoculate and coinoculation crops of vetch in pure form and in the composition of two-component mixtures.

Optimization of information data analyzed in the process of neural network prediction outcome pathology of hemostasis Neural network systems for diagnostics and prognosis are actively introduced in clinical practices in last five years. These systems have higher detection sensitivity and specificity compared to traditional scales for valuation status severity. However the description most of these systems are not include information of principles and algorithms for selection neural network input parameters. Often this leads to redundancy of researched parameters, which in turn have negative impact upon work result of neural network systems. In this article proposed to the algorithm of informative parameters selection for information data optimization, analyzed in process neural network prognosis of outcome pathology hemostasis. neural network, algorithm, informative parameter.

To the question of enhancing of productivity for flat open systems for microalgae culturing E. Onyshchenko In our research we identify the ways to enhance industrial productivity of green microalgae culturing in open pond systems. For effective large - scale implementation of controlled culturing, technologies providing high productive growth in conditions of natural light irradiation are required. Light conversion efficiency with two different culturing methods for Chlorella in conditions duplicating light energy density, typical for middle latitude meteo- climatological conditions is compared.

Behavioral effects of female sex hormones of different nature of the immobilized male white rats Frolova Galina Aleksandrovna, Bogdanova Svetlana Aleksandrovna Found that the sensitivity of male white rats to immobilization stress (10 days of 2 hours) is directly dependent on baseline activity of the animals. Natural female sex steroid estrone (estrone, 1.0 mg/kg, 10 days) caused an inhibition of locomotor and exploratory activity in stressed rats is not dependent on the initial level of activity. Synthetic analogue of the female sex hormone origin of non-steroidal (sinestrol, 0.8 mg/kg, 10 days) in low and intermediate level of stressed rats acts as a stress-limiting factor, high-level direction of impact of sinestrolom coincides with the effects of estrone.

Age and tissue-specific features of the peroxide modification of proteins against the background of emotional-painful stress and preliminary introduction of а-tocopherol Investigated age differences and the level of peroxidation of proteins of male white rats when emotional-painful stress and the introduction of α-tocopherol. The changes in the intensity of peroxide degradation of proteins in various tissues, depending on the age of the animal. Shown as a protective and prooxidant effect of α-tocopherol, depending on the age and the tissue under examination.  

The effect of humic substances and pesticides on the yield of spring wheat The paper presents the research on the effect of humic substances in tank mixtures with pesticides on the structure of the crop, the development of root rot, grain yield and quality of spring wheat.  

Disorders of cellular and humoral immunity ulcer diseases The article deals with contemporary ideas on the state of immunological reactivity under ulcer disease. The role of immune disturbances in the development of clinical manifestations of ulcer disease is shown. Interrelations of different links of the immune system, correlations between specific immunity and natural protection of the organism are considered. Found that patients observed a variety of disorders immunological reactivity. Violations of the immunological reactivity observed in the acute stage and remain in remission.  

The levels of UV-induced mutagenesis change in case of mutations in chromatin-remodeling proteins encoding genes are combined with the rad54 mutation in yeast Saccharomyces cerevisiae Yeast Saccharomyces cerevisiae DOT1, HSM6 and ASF1 genes encode crucial protein chromatin modifiers. We studied the effects of combining dot1, hsm6 and asf1 mutations with rad54 mutation. It’s demonstrated that the enormous increase of UV-induced mutagenesis is representative for dot1rad54, hsm6rad54 and asf1rad54 double mutants. Simultaneously the levels of survival of these double mutants change under the UV light action.

Morphological and physiological parameters of erythrocytes in oxidative stress at different stages of ontogenesis The results indicate the age-related deviations from physiological level of the prevailing number of the investigated morphological and physiological parameters of peripheral erythrocytes functional status, indicating the lack of these indicators stability in the late ontogenesis, significant defects of the gas transmission function of red blood cells, especially presented when inhale rats with hydrogen sulfide gas.  

The effect of Mexidol on clinical and immunological status of patients with chronic obstructive pulmonary disease The assessment of efficiency of meksidol therapy on clinical and immunological status has been made for patients with chronic obstructive pulmonary disease (COPD), the acceptability of physical loads, quality of life and probability of survival of patients with COPD being cousidered against the background of mexidol treatment. It has been established that the use of this preparation in a complex therapy for COPD patients is accompanied by positive dynamics of respiratory symptoms and improves the quality of life of patients. Patients with COPD have a depression of absorbency of neutrophil phagocytics capacity and increasing its metabolic activity with the formation of reactive oxygen species, the probability of a 4 year survival in patients with COPD.